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High performance, easy-to-use mixers for manual to fully automated solution preparation

Mixing is a critical operation within biopharmaceutical processes for many applications, ranging from buffer and media preparation, in-process unit operations such as low pH viral inactivation, to final formulation. The Allegro single-use mixers are part of Pall’s expanding range of Allegro products and services providing integrated process solutions throughout the drug production process. The Allegro mixers combine critical requirements for single-use technologies, such as extreme ease-of-use, with established engineering principles and criteria for robust mixer design to deliver the ultimate in mixing performance.

The Allegro mixers are available in 50 L, 200 L, 500 L and 1000 L sizes, in both standard and jacketed stainless steel tote formats, and can incorporate sensors (e.g. pH, conductivity and temperature) for on-line monitoring and control. Sensor signals can be handled locally on the mixer, or alternatively, can be fed directly to an existing Distributed Control System (DCS) or to an Automated Pall MVP single-use system. With the added capability of load cell integration, the Allegro mixers from Pall can be fully integrated to the Allegro MVP automated single-use systems, providing complete automated process monitoring and control solutions for all applications that require mixing (e.g pH adjustment for buffers and virus inactivation).

Product Features and Benefits

Feature	Benefit
4 pitch blade impeller	Efficient, low shear general purpose mixing over a wide range of applications and shear sensitive soluitons
Impeller rotation in clockwise or counter-clockwise direction	Flexibility to perform both up-flow and down-flow for floating (low density) and settling (high density) fluid or solids

Feature	Benefit
Design principles based on existing Allegro 3D tote format for ease-of-use	Very easy and quick to install and remove the single-use systems pre and post-use

Feature	Benefit
Inflation of the mixer bag	Provides mixing envelope for consistent performance from 50 - 1000 L and the ability to have a gas blanket in operation and mix a range of volumes

Mixer Size	200 L	500 L	1000 L
Minimum Volume (L)*	50	100	155
Maximum Volume (L)	200	500	1000

* minimum volume also covers on-line sensors

Feature	Benefit
Jacketed Totes	Temperature control in appropriate applications

Feature	Benefit
Sensor integration	Allows in-process monitoring and control through integration with automated Allegro MVP systems

Feature	Benefit
Uses existing Allegro film with high clarity and ultra-low extractables	Material/validation consistency across all Allegro biocontainer based systems

Feature	Benefit
Optional baffles available	To assist in reducing air entrapment at high rotation speed for sensitive molecules